TAT-Gap19

Name: TAT-Gap19
Brand: Tocris Bioscience
SKU: 6227

Tocris Bioscience, part of Bio-Techne | Catalog # 6227

Citations (9)

COA / SDS

Cx43 hemichannel blocker

Key Product Details

Description:	Cx43 hemichannel blocker
Purity:	≥95% (HPLC)
Molecular Weight:	2703.28

View Full Technical Details for TAT-Gap19

Technical Data
Citations

Biological Activity for TAT-Gap19

TAT-Gap19 is a Cx43 hemichannel blocker (IC₅₀ ~7 μM). No significant affinity for gap junctions or Panx1 channels. N-terminal transactivator of transcription (TAT) motif promotes membrane permeability and increases inhibitory effect of Gap19 (Cat. No. 5353). Active in vivo. Brain penetrant.

Technical Data for TAT-Gap19

M. Wt	2703.28
Formula	C₁₁₉H₂₁₂N₄₆O₂₆
Single Letter Sequence	YGRKKRRQRRRKQIEIKKFK
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1507930-54-2
PubChem ID	127021051
InChi Key	ALNCFPIRTLVJPY-XELKYWHDNA-N
Smiles	[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TAT-Gap19

Solubility

Soluble to 1mg/ml in water

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References for TAT-Gap19

References are publications that support the biological activity of the product.

Freitas-Andrade and Naus Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1. Neuroscience. 2016 PMID: 25913636
Abudara The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes. Front.Cell.Neurosci. 2014 PMID: 25374505