TC 14012

Name: TC 14012
Brand: Tocris Bioscience
SKU: 4300

Tocris Bioscience, part of Bio-Techne | Catalog # 4300

Citations (13)

COA / SDS

CXCR4 antagonist; ACKR3 (CXCR7) agonist

Key Product Details

Description:	CXCR4 antagonist; ACKR3 (CXCR7) agonist
Purity:	≥95% (HPLC)
Molecular Weight:	2066.43

View Full Technical Details for TC 14012

Technical Data
Citations

Biological Activity for TC 14012

TC 14012 is a CXCR4 antagonist and ACKR3 (CXCR7) agonist (EC₅₀ = 350 nM for CXCR7).

Technical Data for TC 14012

M. Wt	2066.43
Formula	C₉₀H₁₄₀N₃₄O₁₉S₂
Single Letter Sequence	RRACYXKXPYRXCR (Modifications: Disulfide bridge: 4-13, Ala-3 = 3-(2-naphthalenyllalanine), X-6 and X-12 = L-Citrulline, X-8 = D-Citrulline, Arg-14 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	368874-34-4
PubChem ID	90488928
InChi Key	SGDDHDBBOJNZKY-UXNLHULBSA-N
Smiles	[H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TC 14012

Solubility

Soluble to 1mg/ml in water

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References for TC 14012

References are publications that support the biological activity of the product.

Burger Small peptide inhibitors of the CXCR4 chemokine receptor (CS184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells. Blood 2005 PMID: 15905192
Gravel The peptidomimetic CXCR4 antagonist TC14012 recruits beta arrestin to CXCR7: roles of receptor domains. J.Biol.Chem. 2010 PMID: 20956518
Tamamura Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives. Org.Biomol.Chem. 2003 PMID: 14649896