tDHU, acid

Name: tDHU, acid
Brand: Tocris Bioscience
SKU: 7773

Tocris Bioscience, part of Bio-Techne | Catalog # 7773

COA / SDS

Functionalized cereblon ligand for PROTAC development

Key Product Details

Description:	Functionalized cereblon ligand for PROTAC development
Chemical Name:	4-Methyl-3-(tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)benzoic acid
Purity:	≥95% (HPLC)
Molecular Weight:	248.24

View Full Technical Details for tDHU, acid

Technical Data
Citations

Biological Activity for tDHU, acid

tDHU, acid is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a benzoic acid functional handle for ready conjugation to a linker/target protein ligand.

Part of a range of functionalized tool molecules for PROTAC® Degrader R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for tDHU, acid

M. Wt	248.24
Formula	C₁₂H₁₂N₂O₄
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2377643-37-1
PubChem ID	139534352
InChi Key	NXRZIUASGSMTJJ-UHFFFAOYSA-N
Smiles	O=C(C1=CC=C(C)C(N2C(NC(CC2)=O)=O)=C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for tDHU, acid

References are publications that support the biological activity of the product.

Hendrick Direct-to-Biology accelerates PROTAC synthesis and the evaluation of linker effects on permeability and degradation. ACS.Med.Chem.Lett. 2022 PMID: 35859867