Thalidomide 4'-ether-alkylC6-amine

Name: Thalidomide 4'-ether-alkylC6-amine
Brand: Tocris Bioscience
SKU: 6627
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6627

COA / SDS

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Key Product Details

Description:	Cereblon ligand with alkyl linker and terminal amine for onward chemistry
Alternative Names:	Thalidomide - linker 4
Chemical Name:	4-[(6-Aminohexyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
Purity:	≥95% (HPLC)
Molecular Weight:	409.86

View Full Technical Details for Thalidomide 4'-ether-alkylC6-amine

Technical Data
Citations

Biological Activity for Thalidomide 4'-ether-alkylC6-amine

Thalidomide 4'-ether-alkylC6-amine is a functionalized cereblon ligand for PROTAC^® research and development; incorporates an E3 ligase ligand plus a C6 alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTACs R&D.

This product has been recently renamed. The previous name for this product was Thalidomide - linker 4

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for Thalidomide 4'-ether-alkylC6-amine

M. Wt	409.86
Formula	C₁₉H₂₃N₃O₅.HCl
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2245697-88-3
PubChem ID	134812847
InChi Key	HYHUBACBCPALHK-UHFFFAOYSA-N
Smiles	NCCCCCCOC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Thalidomide 4'-ether-alkylC6-amine

References are publications that support the biological activity of the product.

Erb Transcription control by the ENL YEATS domain in acute leukaemia. Nature. 2017 PMID: 28241139
Nabet The dTAG system for immediate and target-specific protein degradation. Nat.Chem.Biol. 2018 PMID: 29581585