Tiotidine

Name: Tiotidine
Brand: Tocris Bioscience
SKU: 0826

Tocris Bioscience, part of Bio-Techne | Catalog # 0826

Citations (33)

COA / SDS

Potent and selective H2 antagonist

Key Product Details

Description:	Potent and selective H₂ antagonist
Alternative Names:	ICI 125,211
Purity:	≥98% (HPLC)
Molecular Weight:	312.41

View Full Technical Details for Tiotidine

Technical Data
Citations

Biological Activity for Tiotidine

Tiotidine is a potent histamine H₂-receptor antagonist with negligible activity against H₁- and H₃- receptors.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data for Tiotidine

M. Wt	312.41
Formula	C₁₀H₁₆N₈S₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	69014-14-8
PubChem ID	50287
InChi Key	YDDXVAXDYKBWDX-UHFFFAOYSA-N
Smiles	CN\C(NCCSCC1=CSC(\N=C(/N)N)=N1)=N/C#N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Tiotidine

	Solvent	Max Conc. mM
Solubility
	ethanol	10
	DMSO	100

Preparing Stock Solutions for Tiotidine

The following data is based on the product molecular weight 312.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.20 mL	16.00 mL	32.01 mL
5 mM	0.64 mL	3.20 mL	6.40 mL
10 mM	0.32 mL	1.60 mL	3.20 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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Reconstitution Calculator

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References for Tiotidine

References are publications that support the biological activity of the product.

Trzeciakowski and Levi The cardiac pharmacology of tiotidine (ICI 125,211): A new histamine H₂- receptor antagonist. J.Pharmacol.Exp.Ther. 1980 PMID: 6105207
Yellin ICI 125,211: A new gastric antisecretory agent acting on histamine H₂- receptors. Life Sci. 1979 PMID: 43449
Hill Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 1990 PMID: 2164693