TNP-ATP triethylammonium salt

Name: TNP-ATP triethylammonium salt
Brand: Tocris Bioscience
SKU: 2464

Tocris Bioscience, part of Bio-Techne | Catalog # 2464

Citations (16)

COA / SDS

Potent and selective P2X antagonist

Key Product Details

Chemical Name:	2',3'-O-(2,4,6-Trinitrophenyl)adenosine-5'-triphosphate tetra(triethylammonium) salt
Purity:	≥95%
Molecular Weight:	1123.04 kDa

View Full Technical Details for TNP-ATP triethylammonium salt

Technical Data
Citations

Biological Activity for TNP-ATP triethylammonium salt

TNP-ATP triethylammonium salt is a high affinity, selective P2X receptor antagonist. Inhibits ATP-induced currents in cells expressing P2X₁, P2X₃ and heteromeric P2X_2/3 receptors with IC₅₀ values of 6, 0.9 and 7 nM respectively. Displays 1000-fold selectivity over P2X₂, P2X₄ and P2X₇.

Technical Data for TNP-ATP triethylammonium salt

M. Wt	1123.04 kDa
Formula	C₁₆H₁₃N₈O₁₉P₃.4C₆H₁₆N
Storage	Store at -20°C
Purity	≥95%

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TNP-ATP triethylammonium salt

Solubility

Soluble Soluble in water (supplied pre-dissolved at a concentration of 10mM)

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References for TNP-ATP triethylammonium salt

References are publications that support the biological activity of the product.

Haam J, Halmos K, Di S, Tasker J Nutritional state-dependent ghrelin activation of vasopressin neurons via retrograde trans-neuronal-glial stimulation of excitatory GABA circuits. J Neurosci, 2014;34(18):6201-13. 2014 PMID: 24790191
Fritsche G, Nairz M, Libby S, Fang F, Weiss G Slc11a1 (Nramp1) impairs growth of Salmonella enterica serovar typhimurium in macrophages via stimulation of lipocalin-2 expression. J Leukoc Biol, 2012;92(2):353-9. 2012 PMID: 22706314
Spelta et al. Kinetics of antagonist actions at rat P2X_2/3 heteromeric receptors. Br.J.Pharmacol., 2002;135:1524 PMID: 11906966
Burgard et al. Competitive antagonism of recombinant P2X_(2/3)receptors by 2', 3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP). Mol.Pharmacol., 2000;58:1502 PMID: 11093790
Virginio et al. Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X₁, P2X₃ and heteromeric P2X_2/3 receptors. Mol.Pharmacol., 1998;53:969 PMID: 9614197
Lewis et al. 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP) - a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels. Br.J.Pharmacol., 1998;124:1463 PMID: 9723959
Thomas et al. The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose channels. J.Physiol., 1998;509.2:411 PMID: 9575290