TP 064

Name: TP 064
Brand: Tocris Bioscience
SKU: 6008

Tocris Bioscience, part of Bio-Techne | Catalog # 6008

Citations (12)

COA / SDS

Potent and selective PRMT 4 inhibitor

Key Product Details

Chemical Name:	N-Methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide
Purity:	≥98%

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Technical Data
Citations

Biological Activity for TP 064

TP 064 is a potent and selective PRMT4 inhibitor; inhibits methylation of H3 (1-25) and MED12 (IC₅₀ values are <10 and 43 nM, respectively). Exhibits >100-fold selectivity over other histone methyltransferases and non-epigenetic targets. Inhibits proliferation of certain multiple myeloma cell lines, arresting cells in G1 phase. TP 064 can be used in vivo. TP 064 inhibits the monocyte/macrophage-driven inflammation in ex vivo.

To request the negative control for TP 064, please fill out the TP 064N request form on the SGC website..

Technical Data for TP 064

Formula	C₂₈H₃₄N₄O₂
Storage	Store at -20°C
Purity	≥98%
CAS Number	2080306-20-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TP 064

Solubility

Soluble Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO

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References for TP 064

References are publications that support the biological activity of the product.

Scheer et al. A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat.Commun., 2019;10:19 PMID: 30604761
Nakayama et al. TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma. Oncotarget, 2018;9:18480 PMID: 29719619

TP 064

Tocris Bioscience, part of Bio-Techne | Catalog # 6008

Key Product Details

Biological Activity for TP 064

Technical Data for TP 064

Solubility for TP 064

Dilution Calculator

Reconstitution Calculator

References for TP 064

Product Documents for TP 064

COA

Certificate of Analysis

SDS

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