TRPV3 74a

Name: TRPV3 74a
Brand: Tocris Bioscience
SKU: 6831

Tocris Bioscience, part of Bio-Techne | Catalog # 6831

COA / SDS

Selective TRPV3 antagonist; brain penetrant

Key Product Details

Description:	Selective TRPV3 antagonist; brain penetrant
Chemical Name:	(αS)-α-[cis-3-Hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-2-pyridinemethanol
Purity:	≥98% (HPLC)
Molecular Weight:	338.32

View Full Technical Details for TRPV3 74a

Technical Data
Citations

Biological Activity for TRPV3 74a

TRPV3 74a is a selective TRPV3 antagonist (K_B = 0.56 μM). Displays no significant activity against a panel of other ion channels. Exhibits efficacy in animal models of neuropathic pain. Brain penetrant.

Technical Data for TRPV3 74a

M. Wt	338.32
Formula	C₁₇H₁₇F₃N₂O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1432051-63-2
PubChem ID	71554840
InChi Key	MTJXDHFAWXGXIN-OAGGEKHMSA-N
Smiles	C[C@]1(C[C@@]([C@@H](C2=CC=CC=N2)O)(C3=CC(C(F)(F)F)=CC=N3)C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for TRPV3 74a

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	33.83	100

Preparing Stock Solutions for TRPV3 74a

The following data is based on the product molecular weight 338.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.96 mL	14.78 mL	29.56 mL
5 mM	0.59 mL	2.96 mL	5.91 mL
10 mM	0.30 mL	1.48 mL	2.96 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

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References for TRPV3 74a

References are publications that support the biological activity of the product.

Gomtsyan Synthesis and pharmacology of (pyridin-2-yl)methanol derivatives as novel and selective transient receptor potential vanilloid 3 antagonists. J.Med.Chem. 2016 PMID: 27077528