UBP 296

Name: UBP 296
Brand: Tocris Bioscience
SKU: 2078

Tocris Bioscience, part of Bio-Techne | Catalog # 2078

Citations (10)

COA / SDS

Potent and selective kainate antagonist; selective for GluK1-containing receptors

Key Product Details

Description:	Potent and selective kainate antagonist; selective for GluK1-containing receptors
Chemical Name:	(RS)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione
Purity:	≥98% (HPLC)
Molecular Weight:	333.3

View Full Technical Details for UBP 296

Technical Data
Citations

Biological Activity for UBP 296

UBP 296 is a selective GluK1 (formally GluR5) subunit containing kainate receptor antagonist (apparent K_D = 1.09 μM). Displays ~ 90-fold selectivity over AMPA receptors and recombinant hGluK2 (formally hGluR6) and GluK5 (formally KA2) containing kainate receptors. Has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers.

Active Enantiomer also available.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data for UBP 296

M. Wt	333.3
Formula	C₁₅H₁₅N₃O₆
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	745055-86-1
PubChem ID	11674376
InChi Key	UUIYULWYHDSXHL-UHFFFAOYSA-N
Smiles	NC(CN1C=CC(=O)N(CC2=C(C=CC=C2)C(O)=O)C1=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UBP 296

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. NaOH	3.33	10 with gentle warming
	DMSO	3.33	10

Preparing Stock Solutions for UBP 296

The following data is based on the product molecular weight 333.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.00 mL	150.02 mL	300.03 mL
0.5 mM	6.00 mL	30.00 mL	60.01 mL
1 mM	3.00 mL	15.00 mL	30.00 mL
5 mM	0.60 mL	3.00 mL	6.00 mL

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References for UBP 296

References are publications that support the biological activity of the product.

Dolman Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. J.Med.Chem. 2005 PMID: 16302825
More Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist. Neuropharmacology 2004 PMID: 15165833