UBP 302

Name: UBP 302
Brand: Tocris Bioscience
SKU: 2079

Tocris Bioscience, part of Bio-Techne | Catalog # 2079

Citations (39)

COA / SDS

Potent and selective kainate antagonist; active enantiomer of UBP 296 (Cat. No. 2078)

Key Product Details

Description:	Potent and selective kainate antagonist; active enantiomer of UBP 296 (Cat. No. 2078)
Chemical Name:	(S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione
Purity:	≥98% (HPLC)
Molecular Weight:	333.3

View Full Technical Details for UBP 302

Technical Data
Citations

Biological Activity for UBP 302

UBP 302 is a potent and selective GluK1 (formally GluR5)-subunit containing kainate receptor antagonist (apparent K_D = 402 nM); active enantiomer of UBP 296 (Cat. No. 2078). Displays ~ 260-fold selectivity over AMPA receptors, ~ 90-fold selectivity over recombinant human GluK2 (formally GluR6) and GluK5 (formally KA2)-containing kainate receptors and has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers. Also protects against soman-induced seizures and neuronal degeneration for up to 30 days when administered one hour after soman exposure.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Compound Libraries for UBP 302

UBP 302 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for UBP 302

M. Wt	333.3
Formula	C₁₅H₁₅N₃O₆
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	745055-91-8
PubChem ID	6420161
InChi Key	UUIYULWYHDSXHL-NSHDSACASA-N
Smiles	O=C(C=CN(C[C@H](N)C(O)=O)C2=O)N2CC1=CC=CC=C1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UBP 302

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. NaOH	8.33	25
	DMSO	6.67	20 with gentle warming

Preparing Stock Solutions for UBP 302

The following data is based on the product molecular weight 333.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	12.00 mL	60.01 mL	120.01 mL
1.25 mM	2.40 mL	12.00 mL	24.00 mL
2.5 mM	1.20 mL	6.00 mL	12.00 mL
12.5 mM	0.24 mL	1.20 mL	2.40 mL

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References for UBP 302

References are publications that support the biological activity of the product.

Dolman Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. J.Med.Chem. 2005 PMID: 16302825
Apland The Limitations of D.pam as a Treatment for Nerve Agent-Induced Seizures and Neuropathology in Rats: Comparison with UBP302. J.Pharmacol.Exp.Ther. 2014 PMID: 25157087
More Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist. Neuropharmacology 2004 PMID: 15165833