VH 101, acid

Name: VH 101, acid
Brand: Tocris Bioscience
SKU: 7758

Tocris Bioscience, part of Bio-Techne | Catalog # 7758

COA / SDS

VHL ligand, carboxylic acid functionalized at the benzylic position

Key Product Details

Description:	VHL ligand, carboxylic acid functionalized at the benzylic position
Chemical Name:	(S)-3-[[[(2S,4R)-1-[(S)-2-(1-Fluorocyclopropan-1-ylcarbonylamino)-3,3-dimethylbutanoyl]-4-hydroxypyrrolidin-2-yl]carbonyl]amino]-3-[4-(4-methylthiazol-5-yl)phenyl]propanoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	574.67

View Full Technical Details for VH 101, acid

Technical Data
Citations

Biological Activity for VH 101, acid

VH 101, acid is a functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC^® research and development; incorporates an E3 ligase ligand with carboxylic acid handle at the benzylic position ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for VH 101, acid

M. Wt	574.67
Formula	C₂₈H₃₅FN₄O₆S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2408341-97-7
PubChem ID	156701284
InChi Key	IWPNYGPPFCLKCL-QTDGGUCWSA-N
Smiles	CC1=C(SC=N1)C2=CC=C([C@H](CC(O)=O)NC([C@@H]3C[C@@H](O)CN3C([C@@H](NC(C4(CC4)F)=O)C(C)(C)C)=O)=O)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for VH 101, acid

References are publications that support the biological activity of the product.

Kofink A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. ChemRxiv - not yet peer reviewed 2022 PMID: 36216795