WWL 123

Name: WWL 123
Brand: Tocris Bioscience
SKU: 5317

Tocris Bioscience, part of Bio-Techne | Catalog # 5317

COA / SDS

α/β-hydrolase domain 6 (ABHD6) inhibitor; antiepileptic

Key Product Details

Description:	α/β-hydrolase domain 6 (ABHD6) inhibitor; antiepileptic
Chemical Name:	N-[[1,1'-Biphenyl]-3-ylmethyl)-N-methylcarbamic acid 4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl ester
Purity:	≥98% (HPLC)
Molecular Weight:	436.5

View Full Technical Details for WWL 123

Technical Data
Citations

Biological Activity for WWL 123

WWL 123 is an α/β-hydrolase domain 6 (ABHD6) inhibitor (IC₅₀ = 0.43 μM). Blocks PTZ-induced seizures in healthy mice and spontaneous seizures in R6/2 mice. Antiepileptic activity is independent of CB₁ and CB₂ receptors, but is GABA_A receptor dependent. Brain penetrant.

Compound Libraries for WWL 123

WWL 123 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Other Information

There appears to be some confusion about the structure of WWL 123. Tocris sells N-[[1,1'-Biphenyl]-3-ylmethyl)-N-methylcarbamic acid 4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl ester [1338574-83-6], which has been confirmed by the inventor, Prof B. Cravatt, as the correct compound. Other vendors sell the corresponding 3-yl regioisomer [1338575-41-9], which is the incorrect compound.

Technical Data for WWL 123

M. Wt	436.5
Formula	C₂₈H₂₄N₂O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1338574-83-6
PubChem ID	90209976
InChi Key	UUJGYRHAOHORFC-UHFFFAOYSA-N
Smiles	NC(C1=CC=C(C2=CC=C(OC(N(C)CC3=CC(C4=CC=CC=C4)=CC=C3)=O)C=C2)C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for WWL 123

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	43.65	100

Preparing Stock Solutions for WWL 123

The following data is based on the product molecular weight 436.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.29 mL	11.45 mL	22.91 mL
5 mM	0.46 mL	2.29 mL	4.58 mL
10 mM	0.23 mL	1.15 mL	2.29 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for WWL 123

References are publications that support the biological activity of the product.

Naydenov ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice. Neuron 2014 PMID: 25033180