YKL 5-124

Name: YKL 5-124
Brand: Tocris Bioscience
SKU: 7157

Tocris Bioscience, part of Bio-Techne | Catalog # 7157

COA / SDS

Potent and selective CDK7 inhibitor; induces cell cycle arrest

Key Product Details

Description:	Potent and selective CDK7 inhibitor; induces cell cycle arrest
Chemical Name:	N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[[4-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide
Purity:	≥95% (HPLC)
Molecular Weight:	515.62

View Full Technical Details for YKL 5-124

Technical Data
Citations

Biological Activity for YKL 5-124

YKL-5-124 is a potent and selective CDK7/Mat1/CycH and cyclin dependent kinase (CDK7) inhibitor (IC₅₀ values = 9.7 nM and 53.5 nM, respectively). YKL-5-124 shows 100-fold selectivity over CDK9 and CDK2. YKL-5-124 induces cell cycle arrest at the G₁/S transition, inhibits E2F-driven gene expression and inhibits CDK1 and CDK3 T-loop phosphorylation.

Licensing Information

Sold under license from Dana-Farber Cancer Institute.

Technical Data for YKL 5-124

M. Wt	515.62
Formula	C₂₈H₃₃N₇O₃
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	1957203-01-8
PubChem ID	121443990
InChi Key	KPABJHHKKJIDGX-JOCHJYFZSA-N
Smiles	CN(C[C@H](C1=CC=CC=C1)NC(N2CC3=C(C2(C)C)NN=C3NC(C4=CC=C(C=C4)NC(C=C)=O)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for YKL 5-124

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	10.31	20
	ethanol	10.31	20

Preparing Stock Solutions for YKL 5-124

The following data is based on the product molecular weight 515.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	9.70 mL	48.49 mL	96.97 mL
1 mM	1.94 mL	9.70 mL	19.39 mL
2 mM	0.97 mL	4.85 mL	9.70 mL
10 mM	0.19 mL	0.97 mL	1.94 mL

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References for YKL 5-124

References are publications that support the biological activity of the product.

Olson Development of a selective CDK7 covalent inhibitor reveals predominant cell-cycle phenotype. Cell Chem.Biol. 2019 PMID: 30905681