DNAscope™ Assay

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DNAscope ISH Assay

The chromogenic DNA ISH technology, DNAscope Duplex Assay enables accurate and reliable detection of DNA aberrations and spatial arrangements of DNA, where current commercially available fluorescent in situ hybridization (FISH) techniques lack single gene detection specificity, thereby limiting the scale and development of DNA research. 

Accurate And Reliable Detection Of DNA Aberrations With New Chromogenic DNAscope Assay

For accurate and reliable detection of DNA aberrations current commercial FISH techniques fall short on morphological detail due to the use of fluorescent nuclear staining  and rely on expensive high-resolution microscopes to visualize gene rearrangement and copy number variation signals. Additionally, use of Bacterial Artificial Chromosome (BAC) clone-based probes that are large and tend to span multiple genes, lack single gene detection specificity limiting the scale and development of DNA research

To overcome these limitations, we are introducing a new chromogenic DNA in situ hybridization (ISH) technology. DNAscope™ employs the proven “double-Z” probe design and signal amplification system of RNAscope™, enabling rapid and flexible probe development for any DNA target enabling visualization of target in paraffin embedded tissues.

Getting Started

To get started with the DNAscope Duplex Assay you need:

DNAscope™ HD Duplex Reagent Kit (Catalog # 324700)

• DNAscope™ HD Duplex Detection Reagents
• DNAscope Pretreatment Reagents Kit
• 50x wash buffer