New RNAscope Protease-Free Workflow on Roche DISCOVERY ULTRA
Robust performance. Any RNA. Any Protein.
Combine the power of RNAscope in situ hybridization (ISH) with immunohistochemistry (IHC) or immunofluorescence (IF) on the same tissue section.
- Works with antibodies for protease-sensitive epitopes
- Visualize tissue histology and architecture with chromogenic solutions
- Low-plex, high-throughput automated solutions for biomarker detection
- Relevant to cancer, gene therapy, biomarker validation for understanding mechanism of action and efficacy
Same-Tissue RNA & Protein Co-Detection
Watch Customer Webinar
Stacy Star Moskowitz Senior Scientist, Novartis and Aman Tyagi Director of Product Management, ACD, presents how our NEW RNAscope Multiomic assay, incorporating the protease-free workflow enables same-slide, same-tissue section, RNA and protein co-detection.
Gain More Insights for Wide Range of RNA and Protein Biomarkers
Powered by RNAscope Protease-Free Workflows Now on the Roche DISCOVERY ULTRA
Characterize cell and phenotype function
Profile immune cell markers with proteinand activation states with cytokine RNAs.
Interrogate infectious agents
Visualize viral, microbial RNA/DNA with host cell marker proteins.
Validate antibody specificity
Determine the specificity of diagnostic/therapeutic antibodies by simultaneously visualizing RNA and protein for the same marker.
Assess cell and gene therapies
Track TCR/CART cells and AAV in pre-clinical and clinical samples using RNA for engineered sequences along with cell-specific marker proteins.
Confidently Detect Protease-Sensitive Antigens
with the NEW Protease Free Workflow
Protease sensitive antigens such as CD20 can be visualized successfully with optimum signal comparable to standard immunohistochemistry (IHC) protocols using the new RNAscope protease-free workflow.
Improve Signal Quality for Protease-Tolerant Antigens
with the NEW Protease Free Workflow
Protein markers like PD1 that worked previously with the standard workflow showed better signal quality with the new protease-free workflow.
Gain Insights into Tumor Biology
Same Section Multiomics | Fluorescent Detection of RNA & Protein
Detect secreted cytokines with RNA markers to determine activation states and combine with immune cell marker proteins. CD4 protein is a marker of infiltrating T-cells and GZMB is a secreted protein. CD4 antibody is protease sensitive, and the new reagent enabled detection of CD4 along with GZMB RNA on the same section.
Stacy Star Moskowitz Senior Scientist, Novartis demonstrates how she incorporates our NEW protease-free capabilities on the Roche DISCOVERY ULTRA.
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