RNAscope™ Assay

Overview

RNAscope™ assays provide a method for detection of RNA in situ. The “ZZ” probe design provides target specificity, and the signal amplification system provides powerful, sensitive detection. On this page, you can learn more about how the RNAscope technology works and the benefits of using it, ranging from the diverse product portfolio and applications to the unmatched support and publication record.

The scientists at Advanced Cell Diagnostics, a Bio-Techne brand, were inspired to help clinicians and researchers observe and measure RNA expression and observe heterogeneity in expression patterns while maintaining morphological context. ACD revolutionized the RNA in situ hybridization method and in 2011, introduced RNAscope ISH for detection of target RNA within intact cells. The proprietary probe design, which simultaneously amplifies target-specific signals while suppressing background noise from non-specific hybridization, represented a major advance in RNA ISH approaches. Known for its sensitivity and specificity, RNAscope ISH is now a proven pioneering technology in the advancing field of spatial genomics, featured in over 10,000 publications across a multitude of research areas. We offer both comprehensive Professional Assay Services as well as the kits, accessories and probes for over 50,000 targets in more than 450 species to enable you conduct single cell spatial gene expression assays in the lab.