Agrin: Proteins and Enzymes
Agrin is a 400-600 kDa heparan sulfate proteoglycan component of the extracellular matrix. Multiple forms of are generated by alternative splicing and proteolytic cleavage. Agrin binds to BMP-2, BMP-4, and TGF-beta, and it blocks BMP-induced signaling through BMPR-IA. Agrin binds to a complex of alpha-Dystroglycan, MuSK, and LRP4 on myotubes and induces the clustering of AChR and motoneuron-myotube adhesion at the neuromuscular junction.
It binds the Abeta (1-40) peptide in Alzheimer’s disease plaques, promotes amyloid fibril formation, and regulates neuronal excitability. It also binds the gp41 coat protein of HIV-1 and functions as an epithelial cell-virus attachment receptor. During T cell activation, Agrin contributes to the formation of the immunological synapse and regulates the threshold of T cell activation. Agrin is upregulated in hepatocellular carcinoma, where it enhances cell proliferation and tumor progression.
Products:
5 results for "Agrin Proteins and Enzymes" in Products
5 results for "Agrin Proteins and Enzymes" in Products
Agrin: Proteins and Enzymes
Agrin is a 400-600 kDa heparan sulfate proteoglycan component of the extracellular matrix. Multiple forms of are generated by alternative splicing and proteolytic cleavage. Agrin binds to BMP-2, BMP-4, and TGF-beta, and it blocks BMP-induced signaling through BMPR-IA. Agrin binds to a complex of alpha-Dystroglycan, MuSK, and LRP4 on myotubes and induces the clustering of AChR and motoneuron-myotube adhesion at the neuromuscular junction.
It binds the Abeta (1-40) peptide in Alzheimer’s disease plaques, promotes amyloid fibril formation, and regulates neuronal excitability. It also binds the gp41 coat protein of HIV-1 and functions as an epithelial cell-virus attachment receptor. During T cell activation, Agrin contributes to the formation of the immunological synapse and regulates the threshold of T cell activation. Agrin is upregulated in hepatocellular carcinoma, where it enhances cell proliferation and tumor progression.
Products:
| Source: | Sf 21 (baculovirus) |
| Accession #: | P25304.2 |
| Applications: | BA, BA |
| Source: | CHO |
| Accession #: | NP_940978 |
| Applications: | BA |
| Accession #: | A2ASQ1.1 |
| Applications: | BA |
| Source: | CHO |
| Accession #: | O00468 |
| Applications: | BA |
| Applications: | AC |