Aminopeptidase PILS/ARTS1: cDNA Clones

The name of Aminopetidase PILS (Puromycin-insensitive Leucyl-specific) describes the two basic properties of this zinc metalloproteinase in vitro. Also known as ALAP (Adipocyte-derived Leucine Aminopeptidase), Aminopeptidase regulator of TNFR1 shedding 1 (ARTS1), and ER Aminopeptidase ERAP1 or ERAAP, it is encoded by the ARTS1 gene. Aminopeptidase PILS is thought to regulate antigen presentation, promote TNFR1 and IL-6 R ectodomain shedding, and may be associated with hypertension.