APH1A Products
Anterior pharynx-defective 1 (APH1A) is a widely expressed 36 kDa 7-transmembrane protein found in the endoplasmic reticulum and Golgi. APH1A is a component of the gamma secretase proteolytic complex which cleaves multiple substrates within their transmembrane domains. This activity liberates the intracellular domains of ErbB4, Neuregulin-1, and Notch receptors in addition to the A-beta peptide from the amyloid precursor protein (APP). Alternate splicing generates a short isoform of human APH1a that lacks 18 amino acids at the C-terminus.
16 results for "APH1A" in Products
16 results for "APH1A" in Products
APH1A Products
Anterior pharynx-defective 1 (APH1A) is a widely expressed 36 kDa 7-transmembrane protein found in the endoplasmic reticulum and Golgi. APH1A is a component of the gamma secretase proteolytic complex which cleaves multiple substrates within their transmembrane domains. This activity liberates the intracellular domains of ErbB4, Neuregulin-1, and Notch receptors in addition to the A-beta peptide from the amyloid precursor protein (APP). Alternate splicing generates a short isoform of human APH1a that lacks 18 amino acids at the C-terminus.
| Reactivity: | Human, Canine, Bovine, Primate, Equine, +1 More |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: APH1A Antibody [NBP2-27176]](https://resources.bio-techne.com/images/products/APH1a-Antibody-Western-Blot-NBP2-27176-img0001.jpg "Western Blot: APH1A Antibody [NBP2-27176]")
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, IP, ChIP |
![Western Blot: APH1A Antibody [NB100-74360]](https://resources.bio-techne.com/images/products/APH1A-Antibody-Western-Blot-NB100-74360-img0006.jpg "Western Blot: APH1A Antibody [NB100-74360]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #665404 |
| Applications: | IHC |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF |
![Western Blot: APH1A AntibodyAzide and BSA Free [NBP2-92623]](https://resources.bio-techne.com/images/products/APH1A-Antibody-Western-Blot-NBP2-92623-img0002.jpg "Western Blot: APH1A AntibodyAzide and BSA Free [NBP2-92623]")
| Applications: | WB |
![Western Blot: APH1A Overexpression Lysate [NBP2-04350]](https://resources.bio-techne.com/images/products/APH1a-Overexpression-Lysate-Adult-Normal-Western-Blot-NBP2-04350-img0001.jpg "Western Blot: APH1A Overexpression Lysate [NBP2-04350]")
| Applications: | WB |
![Western Blot: APH1A Overexpression Lysate [NBP2-08465]](https://resources.bio-techne.com/images/products/APH1a-Overexpression-Lysate-Adult-Normal-Western-Blot-NBP2-08465-img0001.jpg "Western Blot: APH1A Overexpression Lysate [NBP2-08465]")
γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling
| Chemical Name: | (2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine 1,1-dimethylethyl ester |
| Purity: | ≥99% (HPLC) |
DAPT synthesized to Ancillary Material Grade
| Chemical Name: | (2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenylglycine 1,1-dimethylethyl ester |
| Purity: | ≥99% |
γ-secretase inhibitor; inhibits Notch pathway
| Alternate Names: | Dibenzazepine,YO-01027 |
| Chemical Name: | N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide |
| Purity: | ≥98% (HPLC) |
Potent γ-secretase inhibitor
| Chemical Name: | (2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]pentanamide dihydrobromide |
| Purity: | ≥98% (HPLC) |
γ-secretase inhibitor; attenuates amyloid plaque deposition
| Chemical Name: | N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide |
| Purity: | ≥99% (HPLC) |
Highly potent γ-secretase inhibitor; orally bioavailable
| Alternate Names: | BMS-708163 |
| Chemical Name: | (2R)-2-[[(4-Chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide |
| Purity: | ≥98% (HPLC) |
Potent γ-secretase inhibitor
| Chemical Name: | 2-[(1R)-1-[[(4-Chlorophenyl)sulfonyl](2,5-difluorophenyl)amino]ethyl-5-fluorobenzenebutanoic acid |
| Purity: | ≥98% (HPLC) |
γ-secretase pseudo-inhibitor
| Chemical Name: | (2S)-2-Hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]butanamide |
| Purity: | ≥98% (HPLC) |
