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APP Products

Amyloid Precursor Protein (APP) is a type I transmembrane protein that is ubiquitously expressed on cell surfaces. It undergoes complex proteolytic processing and is cleaved by alpha-, beta-, and gamma-Secretases to generate soluble APP alpha, soluble APP beta, and Amyloid beta (A beta) fragments of several lengths. One of these fragments, A beta 42, generated by beta- and gamma-Secretase activities, has been implicated in Alzheimer's disease. Aberrantly high levels of this peptide form and accumulate in the brains of Alzheimer's disease patients to create the senile plaques characteristic of the disease.

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149 results for "APP" in Products

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149 results for "APP" in Products

APP Products

Amyloid Precursor Protein (APP) is a type I transmembrane protein that is ubiquitously expressed on cell surfaces. It undergoes complex proteolytic processing and is cleaved by alpha-, beta-, and gamma-Secretases to generate soluble APP alpha, soluble APP beta, and Amyloid beta (A beta) fragments of several lengths. One of these fragments, A beta 42, generated by beta- and gamma-Secretase activities, has been implicated in Alzheimer's disease. Aberrantly high levels of this peptide form and accumulate in the brains of Alzheimer's disease patients to create the senile plaques characteristic of the disease.

Products:

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Applications: WB
Applications: ELISA
Applications: AC
Applications: ELISA
Reactivity: Human
Applications: IHC, WB
Reactivity: Human, Mouse, Rat
Applications: ELISA
Reactivity: Human
Applications: IHC, WB
Reactivity: Human, Mouse, Rat
Applications: ELISA
Reactivity: Human
Applications: IHC, WB, ICC/IF, Flow, CyTOF-ready
Reactivity: Human
Applications: IHC, WB
Reactivity: Human, Mouse, Rat
Applications: IHC, WB, ICC/IF, Flow, CyTOF-ready
Reactivity: Human
Applications: IHC, WB, ICC/IF, Flow, CyTOF-ready
Reactivity: Human
Applications: IHC, WB
Reactivity: Human, Mouse, Rat
Applications: ELISA
Reactivity: Human
Applications: IHC, WB, ICC/IF, Flow, CyTOF-ready
Reactivity: Human
Applications: IHC, WB, ICC/IF, Flow, CyTOF-ready
Reactivity: Human
Applications: IHC, WB
Reactivity: Human, Mouse, Rat

Predominant amyloid β-protein fragment

Amyloid β-protein fragment

Applications: WB, IHC
Reactivity: Human

Human amyloid β-protein fragment functionally required for neurotoxicity

Applications: WB, IP
Reactivity: Human
Applications: IHC, WB, ICC/IF, Flow
Reactivity: Human
Applications: WB, ELISA, ICC/IF, Flow
Reactivity: Human, Mouse
Applications: IHC, WB
Reactivity: Human, Mouse, Rat
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