B-Raf Products
The Raf serine/threonine kinases are effectors of Ras that function as MAP3Ks in the ERK phosphorylation cascade. Mammals express three Raf proteins: Raf-1 (C-Raf); A-Raf; and B-Raf, strongly expressed in fetal brain and adult cerebrum. Mice with a targeted disruption of the B-raf gene die of vascular defects during mid-gestation. B-raf mutations have been found in two-thirds of malignant melanomas, with the single substitution V599E in the kinase domain the most frequent occurrence.
94 results for "B-Raf" in Products
94 results for "B-Raf" in Products
B-Raf Products
The Raf serine/threonine kinases are effectors of Ras that function as MAP3Ks in the ERK phosphorylation cascade. Mammals express three Raf proteins: Raf-1 (C-Raf); A-Raf; and B-Raf, strongly expressed in fetal brain and adult cerebrum. Mice with a targeted disruption of the B-raf gene die of vascular defects during mid-gestation. B-raf mutations have been found in two-thirds of malignant melanomas, with the single substitution V599E in the kinase domain the most frequent occurrence.
Potent B-Raf inhibitor
| Chemical Name: | 2,3-Dihydro-5-[1-(2-hydroxyethyl)-3-(4-pyridinyl)-1H-pyrazol-4-yl]-1H-inden-1-one oxime |
| Purity: | ≥98% (HPLC) |
Selective BRAF-V600E protein Degrader (uSMITE™)
| Chemical Name: | N-[[4-[3-[2,6-Difluoro-3-[(propylsulfonyl)amino]benzoyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]phenyl]methyl]-5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]pentanamide |
| Purity: | ≥98% (HPLC) |
Potent BRAF and CRAF inhibitor
| Chemical Name: | N-[3-[[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide |
| Purity: | ≥98% (HPLC) |
Potent BRAF Degrader (PROTAC®
| Chemical Name: | (2S,4R)-1-((S)-2-(2-(4-(4-(3-(2,6-Difluoro-3-(propylsulfonamido)benzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF |
![Western Blot: B-Raf AntibodyBSA Free [NBP2-41219]](https://resources.bio-techne.com/images/products/B-Raf-Antibody-Western-Blot-NBP2-41219-img0004.jpg "Western Blot: B-Raf AntibodyBSA Free [NBP2-41219]")
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #RM8 |
| Applications: | IHC, WB, ELISA, ICC/IF |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Simple Western |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, Simple Western |
![Western Blot: B-Raf Antibody [NBP1-89942]](https://resources.bio-techne.com/images/products/B-Raf-Antibody-Western-Blot-NBP1-89942-img0015.jpg "Western Blot: B-Raf Antibody [NBP1-89942]")
| Reactivity: | Human, Mouse, Rat, Monkey |
| Details: | Mouse IgG1 Monoclonal Clone #OTI5A9 |
| Applications: | IHC, WB, ICC/IF, Flow, IP |
![Western Blot: B-Raf Antibody (OTI5A9) [NBP1-47668]](https://resources.bio-techne.com/images/products/B-Raf-Antibody-OTI5A9-Western-Blot-NBP1-47668-img0019.jpg "Western Blot: B-Raf Antibody (OTI5A9) [NBP1-47668]")
Potent B-Raf inhibitor
| Chemical Name: | 5-[2-[4-[2-(Dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2a Monoclonal Clone #336016 |
| Applications: | WB |
| Applications: | ELISA |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, IP |
![Immunohistochemistry-Paraffin: B-Raf Antibody [NBP2-15531]](https://resources.bio-techne.com/images/products/B-Raf-Antibody-Immunohistochemistry-Paraffin-NBP2-15531-img0008.jpg "Immunohistochemistry-Paraffin: B-Raf Antibody [NBP2-15531]")
| Reactivity: | Human |
| Details: | Mouse IgG2B Monoclonal Clone #CL4004 |
| Applications: | IHC, WB |
![Western Blot: B-Raf Antibody (CL4004) [NBP2-59035]](https://resources.bio-techne.com/images/products/B-Raf-Antibody-CL4004-Western-Blot-NBP2-59035-img0005.jpg "Western Blot: B-Raf Antibody (CL4004) [NBP2-59035]")
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG1 Monoclonal Clone #1H12 |
| Applications: | IHC, WB, ELISA, ICC/IF |
![Western Blot: B-Raf Antibody (1H12)BSA Free [NBP1-47433]](https://resources.bio-techne.com/images/products/B-Raf-Antibody-1H12-Western-Blot-NBP1-47433-img0010.jpg "Western Blot: B-Raf Antibody (1H12)BSA Free [NBP1-47433]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #1H12F1 |
| Applications: | IHC, WB, ELISA |
![Western Blot: B-Raf Antibody (1H12F1)BSA Free [NBP1-47555]](https://resources.bio-techne.com/images/products/B-Raf-Antibody-1H12F1-Western-Blot-NBP1-47555-img0004.jpg "Western Blot: B-Raf Antibody (1H12F1)BSA Free [NBP1-47555]")
Potent and selective B-Raf, CDK16 and NEK9 inhibitor; anticancer; also targets human proteins in the SARS-CoV-2 interactome
| Chemical Name: | N-[3-[5-(2-Aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide methanesulfonate |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #CL4003 |
| Applications: | IHC, WB |
![Western Blot: B-Raf Antibody (CL4003) [NBP2-59034]](https://resources.bio-techne.com/images/products/B-Raf-Antibody-CL4003-Western-Blot-NBP2-59034-img0005.jpg "Western Blot: B-Raf Antibody (CL4003) [NBP2-59034]")
| Reactivity: | Human |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #IHC600 |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: B-Raf Antibody (IHC600) - V600-E Mutation [NBP3-00517]](https://resources.bio-techne.com/images/products/B-Raf-Antibody-IHC600-V600-E-Mutation-Immunohistochemistry-Paraffin-NBP3-00517-img0002.jpg "Immunohistochemistry-Paraffin: B-Raf Antibody (IHC600) - V600-E Mutation [NBP3-00517]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #S05-9B6 |
| Applications: | WB |
Potent Raf kinase inhibitor
| Chemical Name: | 3-(1-Cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]benzamide |
| Purity: | ≥98% (HPLC) |
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor
| Chemical Name: | 2-(Methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]-4-pyrimidinamine |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF |
![Western Blot: B-Raf Antibody [NBP2-58818]](https://resources.bio-techne.com/images/products/B-Raf-Antibody-Western-Blot-NBP2-58818-img0003.jpg "Western Blot: B-Raf Antibody [NBP2-58818]")
Potent and selective BRAFV600E Degrader (PROTAC®)
| Chemical Name: | (2S,4R)-1-((S)-2-(2-(4-(4-(3-(3-((N-Ethyl-N-methylsulfamoyl)amino)-2,6-difluorobenzoyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥98% (HPLC) |
Negative control for CG 858 (Cat. No. 7427)
| Chemical Name: | N-[[4-[3-[2,6-Difluoro-3-[(propylsulfonyl)amino]benzoyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]phenyl]methyl]-5-[[2-(1-methyl-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]pentanamide |
| Purity: | ≥98% (HPLC) |
