Carnosine Dipeptidase 1/CNDP1: Proteins and Enzymes

CNDP1, also known as X-His Dipeptidase, Glutamate Carboxypeptidase-like Protein 2 (CPGL2) or Carnosinase 1 (CN1), is a secreted dipeptidase with a narrow specificity for Xaa-His dipeptides including those with Xaa=beta-Ala (carnosine) and Xaa=gamma-aminobutyric acid (homocarnosine), two naturally occurring dipeptides with potential neuroprotective and neurotransmitter functions in the brain. In comparison, a closely related protein known as CNDP2, CPGL or CN2, is a cytosolic nonspecific dipeptidase.