CD1a Products
Cluster of Differentiation 1a (CD1a) is a transmembrane glycoprotein in the CD1 family of MHC-like molecules. It is expressed by most mammals but not by mice or rats. Human CD1a is a 311 amino acid protein with a predicted molecular mass of 49 kDa. It binds to lipid and glycolipid antigens and presents them to T cells. Antigen-presenting cells, Langerhans cells, and thymocytes express CD1a, where it traffics between endosomes and plasma membrane lipid rafts. Heterodimerization with beta-2-Microglobulin is required for CD1a membrane trafficking, and CD1a binding to exogenous lipids results in CD1a protein stability. The activation of thymus-localized T cells during the development of Graves’ disease and Hashimoto’s thyroiditis may be initiated by CD1a expressed by CD83+ dendritic cells.
403 results for "CD1a" in Products
403 results for "CD1a" in Products
CD1a Products
Cluster of Differentiation 1a (CD1a) is a transmembrane glycoprotein in the CD1 family of MHC-like molecules. It is expressed by most mammals but not by mice or rats. Human CD1a is a 311 amino acid protein with a predicted molecular mass of 49 kDa. It binds to lipid and glycolipid antigens and presents them to T cells. Antigen-presenting cells, Langerhans cells, and thymocytes express CD1a, where it traffics between endosomes and plasma membrane lipid rafts. Heterodimerization with beta-2-Microglobulin is required for CD1a membrane trafficking, and CD1a binding to exogenous lipids results in CD1a protein stability. The activation of thymus-localized T cells during the development of Graves’ disease and Hashimoto’s thyroiditis may be initiated by CD1a expressed by CD83+ dendritic cells.
Reactivity: | Human, Canine |
Details: | Mouse IgG2A Monoclonal Clone #NA1/34-HLK |
Applications: | IHC, ICC/IF, Flow |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #703217 |
Applications: | Flow, IHC, CyTOF-ready, ICC |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #703217 |
Applications: | Flow |
Clone O10 was used by HLDA to establish CD designation.
Reactivity: | Human, Rhesus Macaque |
Details: | Mouse IgG1 kappa Monoclonal Clone #O10 |
Applications: | IHC, WB, ICC/IF, Flow |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #703217 |
Applications: | Flow |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #703217 |
Applications: | Flow |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #703217 |
Applications: | Flow |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #703217 |
Applications: | Flow |
Reactivity: | Human |
Details: | Mouse IgM Monoclonal Clone #214A9.01 |
Applications: | IHC, Flow |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #703217 |
Applications: | Flow |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #703217 |
Applications: | Flow |
Recombinant Monoclonal Antibody.
Reactivity: | Human |
Details: | Rabbit IgG Monoclonal Clone #C1A/1506R |
Applications: | IHC, MA |
Reactivity: | Human |
Details: | Mouse IgG1 Kappa/IgG1 Kappa Monoclonal Clone #O10+C1A/711 |
Applications: | IHC, ICC/IF, Flow |
Reactivity: | Human, Porcine |
Details: | Mouse IgG1 Monoclonal Clone #201B5.08 |
Applications: | IHC, ELISA, Flow |
Reactivity: | Human |
Details: | Mouse IgG1 kappa Monoclonal Clone #SPM120 |
Applications: | IHC, ICC/IF, Flow |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #703217 |
Applications: | Flow |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #703217 |
Applications: | Flow |
Applications: | PAGE |
Recombinant Monoclonal Antibody
Reactivity: | Human |
Details: | Mouse IgG1 kappa Monoclonal Clone #rC1A/8110 |
Applications: | IHC |
Recombinant Monoclonal Antibody
Reactivity: | Human |
Details: | Rabbit IgG Kappa Monoclonal Clone #C1A/8111R |
Applications: | IHC |
Reactivity: | Human, Mouse |
Details: | Mouse IgG2b Kappa Monoclonal Clone #CB-T6 |
Applications: | ICC/IF, Flow |
Reactivity: | Human |
Details: | Mouse IgG1 kappa Monoclonal Clone #C1A/711 |
Applications: | IHC |
Recombinant Monoclonal Antibody
Reactivity: | Human |
Details: | Rabbit IgG Kappa Monoclonal Clone #CBT6 |
Applications: | IHC, ELISA, ICC/IF, Flow, IP |