CD27 Ligand/TNFSF7: Proteins and Enzymes

CD27 Ligand, also known as CD70 and TNFSF7, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF). CD27 Ligand expression is induced by antigen-receptor activation in B cells. CD27/TNFRSF7 is expressed on natural killer (NK) cells and subsets of T and B cells. CD27 ligation on NK cells induces proliferation and IFN production. CD27 ligation on T cells provides a co-stimulatory signal required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD27 ligation on B cells inhibits terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses.