Chordin-like 2/CHRDL2: Proteins and Enzymes
Chordin-like 2 (CHL2, CHRDL2, or BNF-1), is a secreted glycoprotein that functions as a BMP antagonist. It is expressed in chondrocytes in developing joint cartilage, osteoblasts, myotubes, brain, some carcinomas, and the genitourinary system (e.g. uterus, prostate, testis, bladder).
CHL2 binds to multiple TGF-beta superfamily proteins including BMP-2, -4, -5, -6, -7, GDF-5, Activin A, and TSG. It prevents the binding of BMPs to type 1 and type 2 receptors as well as BMP-induced cellular responses. CHL2 reduces the rate of matrix deposition by mesenchymal cells, acting as a negative regulator of cartilage formation.
Products:
4 results for "Chordin-like 2/CHRDL2 Proteins and Enzymes" in Products
4 results for "Chordin-like 2/CHRDL2 Proteins and Enzymes" in Products
Chordin-like 2/CHRDL2: Proteins and Enzymes
Chordin-like 2 (CHL2, CHRDL2, or BNF-1), is a secreted glycoprotein that functions as a BMP antagonist. It is expressed in chondrocytes in developing joint cartilage, osteoblasts, myotubes, brain, some carcinomas, and the genitourinary system (e.g. uterus, prostate, testis, bladder).
CHL2 binds to multiple TGF-beta superfamily proteins including BMP-2, -4, -5, -6, -7, GDF-5, Activin A, and TSG. It prevents the binding of BMPs to type 1 and type 2 receptors as well as BMP-induced cellular responses. CHL2 reduces the rate of matrix deposition by mesenchymal cells, acting as a negative regulator of cartilage formation.
Products:
| Applications: | AC |
| Applications: | AC |
| Source: | NS0 |
| Accession #: | Q8VEA6.1 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | Q6WN34 |
| Applications: | BA |