CLEC-2/CLEC1B: Proteins and Enzymes
CLEC-2 (C-type lectin-like receptor 2), also known as CLEC-1B, is a transmembrane glycoprotein that is expressed on platelets, megakaryocyte, and liver sinusoidal cells. CLEC-2 binding to Podoplanin triggers platelet activation, shedding of GPVI, and cleavage of Fcgamma RIIA/CD32a. CLEC-2 expression on platelets is required for the development of lymphatic vessels and valves as well as the maintenance of lymph node high endothelial veinules (HEV) during lymphocyte crossing.
CLEC-2 additionally binds to fucoidan, HIV-1, and the platelet-aggregating snake venom protein Rhodocytin/Aggretin. In the liver, soluble CLEC-2 promotes M2 macrophage differentiation and limits inflammatory cytokine production.
Products:
3 results for "CLEC-2/CLEC1B Proteins and Enzymes" in Products
3 results for "CLEC-2/CLEC1B Proteins and Enzymes" in Products
CLEC-2/CLEC1B: Proteins and Enzymes
CLEC-2 (C-type lectin-like receptor 2), also known as CLEC-1B, is a transmembrane glycoprotein that is expressed on platelets, megakaryocyte, and liver sinusoidal cells. CLEC-2 binding to Podoplanin triggers platelet activation, shedding of GPVI, and cleavage of Fcgamma RIIA/CD32a. CLEC-2 expression on platelets is required for the development of lymphatic vessels and valves as well as the maintenance of lymph node high endothelial veinules (HEV) during lymphocyte crossing.
CLEC-2 additionally binds to fucoidan, HIV-1, and the platelet-aggregating snake venom protein Rhodocytin/Aggretin. In the liver, soluble CLEC-2 promotes M2 macrophage differentiation and limits inflammatory cytokine production.
Products:
| Source: | NS0 |
| Accession #: | AAF36777 |
| Applications: | BA |
| Source: | CHO |
| Accession #: | Q9P126.2 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | Q9JL99 |
| Applications: | BA |
