Contactin-4: cDNA Clones

Contactin-4 (CNTN4), also known as BIG-2 (brain-derived immunoglobulin superfamily molecule 2), is an axonal cell adhesion molecule that belongs to the contactin family, a subfamily of the Ig superfamily. Contactin family members are characterized by the presence of six Ig-like domains, four fibronectin type III-like repeats, and a glycosylphosphatidylinositol (GPI)-anchoring domain. Three alternative transcripts of CNTN4, encoding isoforms a, b, and c precursor proteins containing 1026, 282, and 698 amino acid residues, respectively, have been described.