CTGF/CCN2: cDNA Clones
CTGF belongs to the CCN (CYR61/CTGF/NOV) family of secreted proteins that share a common multimodular organization. Each protein contains an IGF-binding protein domain, a von Willebrand factor type C domain, a thrombospondin type I domain, and a cysteine knot domain. The multimodular CTGF can bind multiple ligands and has numerous effects on development, differentiation, and disease. The C-terminal cysteine knot motif contains the HSPG (proteoglycan) and low-density lipoprotein receptor (LDLR) binding sites that contribute to the adhesive and mitogenic properties of CTGF.
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CTGF/CCN2: cDNA Clones
CTGF belongs to the CCN (CYR61/CTGF/NOV) family of secreted proteins that share a common multimodular organization. Each protein contains an IGF-binding protein domain, a von Willebrand factor type C domain, a thrombospondin type I domain, and a cysteine knot domain. The multimodular CTGF can bind multiple ligands and has numerous effects on development, differentiation, and disease. The C-terminal cysteine knot motif contains the HSPG (proteoglycan) and low-density lipoprotein receptor (LDLR) binding sites that contribute to the adhesive and mitogenic properties of CTGF.
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