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CTLA-4 Products

CTLA-4/CD152 (Cytotoxic T-Lymphocyte Antigen 4) is a transmembrane T cell inhibitory molecule that is expressed as a covalent homodimer. CTLA-4 is recruited from intracellular vesicles to the immunological synapse beginning 1-2 days after T cell activation. It forms a linear lattice with B7-1 on APC, inducing negative regulatory signals and ending CD28-dependent T cell activation. Mice deleted for CTLA-4 develop lethal autoimmune reactions due to continued T cell activation and poor control by regulatory T cells which constitutively express CTLA-4.

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638 results for "CTLA-4" in Products

638 results for "CTLA-4" in Products

CTLA-4 Products

CTLA-4/CD152 (Cytotoxic T-Lymphocyte Antigen 4) is a transmembrane T cell inhibitory molecule that is expressed as a covalent homodimer. CTLA-4 is recruited from intracellular vesicles to the immunological synapse beginning 1-2 days after T cell activation. It forms a linear lattice with B7-1 on APC, inducing negative regulatory signals and ending CD28-dependent T cell activation. Mice deleted for CTLA-4 develop lethal autoimmune reactions due to continued T cell activation and poor control by regulatory T cells which constitutively express CTLA-4.

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Applications: ELISA, Flow, Func
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: ELISA, Flow, Func
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: IHC
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: ELISA, Flow, Func
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: IHC
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: IHC
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: ELISA, Flow, Func
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: IHC
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: IHC
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: ELISA, Flow, Func
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: IHC
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: IHC
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: Simple Plex

Build your own multi-plex biomarker immunoassay panel for Ella™. Highly precise and reproducible. Choose from more than 250 fully validated target analytes.

Applications: WB, Flow, CyTOF-ready, ICC
Reactivity: Human
Applications: Ctrl, Simple Plex

Control for use with Human and Non-Human Primate CTLA-4 Simple Plex Cartridge Kit

Applications: BA

Biotinylated

Applications: IHC, ELISA, ICC/IF, Flow, IP
Reactivity: Human
Applications: Flow, CyTOF-ready
Reactivity: Human

Recombinant Monoclonal Antibody For Research Use Only

Applications: ICFlow
Reactivity: Human
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