CTLA-4 Products
CTLA-4/CD152 (Cytotoxic T-Lymphocyte Antigen 4) is a transmembrane T cell inhibitory molecule that is expressed as a covalent homodimer. CTLA-4 is recruited from intracellular vesicles to the immunological synapse beginning 1-2 days after T cell activation. It forms a linear lattice with B7-1 on APC, inducing negative regulatory signals and ending CD28-dependent T cell activation. Mice deleted for CTLA-4 develop lethal autoimmune reactions due to continued T cell activation and poor control by regulatory T cells which constitutively express CTLA-4.
6 results for "CTLA-4" in Products
6 results for "CTLA-4" in Products
CTLA-4 Products
CTLA-4/CD152 (Cytotoxic T-Lymphocyte Antigen 4) is a transmembrane T cell inhibitory molecule that is expressed as a covalent homodimer. CTLA-4 is recruited from intracellular vesicles to the immunological synapse beginning 1-2 days after T cell activation. It forms a linear lattice with B7-1 on APC, inducing negative regulatory signals and ending CD28-dependent T cell activation. Mice deleted for CTLA-4 develop lethal autoimmune reactions due to continued T cell activation and poor control by regulatory T cells which constitutively express CTLA-4.
| Reactivity: | Human, Mouse, Rat, Bovine |
| Details: | Mouse IgG1 kappa Monoclonal Clone #L4P2F5*F10 |
| Applications: | IHC, WB, ELISA |
| Reactivity: | Human, Mouse, Rat, Bovine |
| Details: | Mouse IgG1 kappa Monoclonal Clone #L4P2F5*F10 |
| Applications: | IHC, WB, ELISA |
| Reactivity: | Human, Mouse, Rat, Bovine |
| Details: | Mouse IgG1 kappa Monoclonal Clone #L4P2F5*F10 |
| Applications: | IHC, WB, ELISA |
| Reactivity: | Human, Mouse, Rat, Bovine |
| Details: | Mouse IgG1 kappa Monoclonal Clone #L4P2F5*F10 |
| Applications: | IHC, WB, ELISA |
| Reactivity: | Human, Mouse, Rat, Bovine |
| Details: | Mouse IgG1 kappa Monoclonal Clone #L4P2F5*F10 |
| Applications: | IHC, WB, ELISA |