DMPK Products

DMPK (dystrophia myotonica protein kinase), also called DMK, MDPK or MT-PK (myotonin protein kinase) is a cytoplasmic protein of the Ser/Thr kinase superfamily (EC 2.7.11.1). DMPK includes a protein kinase domain, an AGC kinase C-terminal domain and a coiled-coil negative regulatory domain that mediates dimerization. Twelve isoforms that range in size from 530-634 amino acids. The most prominent, muscle-specific isoform phosphorylates phospholamban and is critical for cardiac contractility.