DNA-dependent Protein Kinase Inhibitors: Small Molecules and Peptides
DNA-PKcs (DNA-dependent protein kinase catalytic subunit) is a member of the PI 3-kinase related kinase (PIKK) superfamily. DNA-PKcs is a serine/threonine kinase that, along with the DNA-binding proteins Ku70/Ku80, binds to regions of DNA double strand breaks, and is involved in double-strand break repair and VDJ recombination.
6 results for "DNA-dependent Protein Kinase Inhibitors Small Molecules and Peptides" in Products
6 results for "DNA-dependent Protein Kinase Inhibitors Small Molecules and Peptides" in Products
DNA-dependent Protein Kinase Inhibitors: Small Molecules and Peptides
DNA-PKcs (DNA-dependent protein kinase catalytic subunit) is a member of the PI 3-kinase related kinase (PIKK) superfamily. DNA-PKcs is a serine/threonine kinase that, along with the DNA-binding proteins Ku70/Ku80, binds to regions of DNA double strand breaks, and is involved in double-strand break repair and VDJ recombination.
Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK
| Alternate Names: | GSK2126458 |
| Chemical Name: | 2,4-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide |
| Purity: | ≥98% (HPLC) |
Potent and selective DNA-PK inhibitor
| Alternate Names: | KU 57788 |
| Chemical Name: | 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one |
| Purity: | ≥99% (HPLC) |
Inhibitor of PI 3-kinase, mTOR and DNA-PK
| Chemical Name: | 3-[4-(4-Morpholinylpyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol hydrochloride |
| Purity: | ≥98% (HPLC) |
Selective DNA-PK inhibitor
| Chemical Name: | 2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one |
| Purity: | ≥98% (HPLC) |
Potent and selective DNA-PK inhibitor; enhances CRISPR-mediated HDR efficiency
| Chemical Name: | 7,9-Dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one |
| Purity: | ≥98% (HPLC) |
Dual DNA-PK and PI 3-K inhibitor
| Chemical Name: | 4-Ethyl-N-[4-[2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-8-yl]-1-dibenzothienyl]-1-piperazineacetamide |
| Purity: | ≥97% (HPLC) |
