DNMT1 Products
DNMT1 (DNA methyltransferase 1; also MCMT and CXXC-type Zn finger protein 9) is a 190 kDa member of the C5-methyltransferase family of enzymes. DNMT1 is ubiquitous in expression, and appears during the S-phase of the cell cycle. DNMT1 catalyzes the attachment of a methyl group to the C5 position of CpG cytosines using AdoMet/adenosylmethionine as a co factor. This acts to silence select genes during X chromosome inactivation and tumorigenesis. Human DNMT1 is 1616 amino acids (aa) in length. DNMT1 contains an N-terminal regulatory, homodimerization and target recognition region (aa 1-1100), a Gly-Lys linker segment (aa 1109-1120) and a catalytic domain (aa 1121-1616). DNMT1 is acetylated, phosphorylated, and SUMOylated. There are multiple splice variants of DNMT1. There is a deletion of aa 1-336, alternative start sites at Met122 and 62 aa upstream of the standard start site, and a 17 aa substitution for Pro149. Over aa 1381-1587, human DNMT1 shares 87% aa identity with mouse DNMT1.
159 results for "DNMT1" in Products
159 results for "DNMT1" in Products
DNMT1 Products
DNMT1 (DNA methyltransferase 1; also MCMT and CXXC-type Zn finger protein 9) is a 190 kDa member of the C5-methyltransferase family of enzymes. DNMT1 is ubiquitous in expression, and appears during the S-phase of the cell cycle. DNMT1 catalyzes the attachment of a methyl group to the C5 position of CpG cytosines using AdoMet/adenosylmethionine as a co factor. This acts to silence select genes during X chromosome inactivation and tumorigenesis. Human DNMT1 is 1616 amino acids (aa) in length. DNMT1 contains an N-terminal regulatory, homodimerization and target recognition region (aa 1-1100), a Gly-Lys linker segment (aa 1109-1120) and a catalytic domain (aa 1121-1616). DNMT1 is acetylated, phosphorylated, and SUMOylated. There are multiple splice variants of DNMT1. There is a deletion of aa 1-336, alternative start sites at Met122 and 62 aa upstream of the standard start site, and a 17 aa substitution for Pro149. Over aa 1381-1587, human DNMT1 shares 87% aa identity with mouse DNMT1.
Reactivity: | Human, Mouse, Rat, Bovine, Porcine, +2 More |
Details: | Mouse IgG1 kappa Monoclonal Clone #60B1220.1 |
Applications: | IHC, WB, ICC/IF, Flow, IP, +4 More |
Reactivity: | Human |
Details: | Mouse IgG2b Kappa Monoclonal Clone #DNMT1/2061 |
Applications: | IHC |
Reactivity: | Human |
Details: | Mouse IgG2b Kappa Monoclonal Clone #DNMT1/2061 |
Applications: | IHC |
Reactivity: | Human |
Details: | Mouse IgG2b Kappa Monoclonal Clone #DNMT1/2061 |
Applications: | IHC |
Reactivity: | Human |
Details: | Mouse IgG2b Kappa Monoclonal Clone #DNMT1/2061 |
Applications: | IHC |
Reactivity: | Human |
Details: | Mouse IgG2b Kappa Monoclonal Clone #DNMT1/2061 |
Applications: | IHC |
Reactivity: | Human |
Details: | Mouse IgG2b Kappa Monoclonal Clone #DNMT1/2061 |
Applications: | IHC |
Reactivity: | Human |
Details: | Sheep IgG Polyclonal |
Applications: | WB, ICC, KO |
Reactivity: | Human, Mouse |
Details: | Rabbit IgG Polyclonal |
Applications: | WB, IP |
Reactivity: | Human, Mouse, Zebrafish, Fish |
Details: | Mouse IgG1 kappa Monoclonal Clone #4G11-C7 |
Applications: | IHC, WB, IP, ChIP |
Reactivity: | Human, Mouse |
Details: | Mouse IgG1 Monoclonal Clone #11H8 |
Applications: | WB, ICC/IF |
Recombinant Monoclonal Antibody
Reactivity: | Human, Mouse, Rat |
Details: | Rabbit IgG Monoclonal Clone #1K5K8 |
Applications: | WB, ELISA, IP |
Applications: | Func |
Applications: | Func |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC |
Recombinant monoclonal antibody expressed in HEK293F cells
Reactivity: | Human |
Details: | Rabbit IgG Monoclonal Clone #1A9 |
Applications: | IHC, ELISA, ICC/IF |
Recombinant Monoclonal Antibody
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #A3A8-R |
Applications: | WB, ICC/IF |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC, ICC/IF |
Applications: | ELISA |
Applications: | WB, ELISA, MA, AP |
Applications: | NULL |
Applications: | ELISA |
Applications: | AC |
Reactivity: | Human, Mouse, Rat, Bovine, Porcine, +1 More |
Details: | Mouse IgG1 kappa Monoclonal Clone #60B1220.1 |
Applications: | IHC, WB, ICC/IF, Flow, IP, +4 More |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC, ICC/IF |