FAK: Small Molecules and Peptides
FAK (Focal Adhesion Kinase) is a non-receptor protein tyrosine kinase involved in signal transduction from integrin-enriched focal adhesion sites that mediate cell contact with the extracellular matrix. FAK-enhanced signals have been shown to mediate the survival of anchorage-dependent cells and are critical for efficient cell migration in response to growth factor receptor and integrin stimulation. Elevated expression of FAK in human tumors has been correlated with increased malignancy and invasiveness.
8 results for "FAK Small Molecules and Peptides" in Products
8 results for "FAK Small Molecules and Peptides" in Products
FAK: Small Molecules and Peptides
FAK (Focal Adhesion Kinase) is a non-receptor protein tyrosine kinase involved in signal transduction from integrin-enriched focal adhesion sites that mediate cell contact with the extracellular matrix. FAK-enhanced signals have been shown to mediate the survival of anchorage-dependent cells and are critical for efficient cell migration in response to growth factor receptor and integrin stimulation. Elevated expression of FAK in human tumors has been correlated with increased malignancy and invasiveness.
Selective FAK inhibitor
| Alternate Names: | Y15,NSC 677249 |
| Chemical Name: | 1,2,4,5-Benzenetetramine tetrahydrochloride |
Potent and selective FAK inhibitor
| Chemical Name: | 3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone |
| Purity: | ≥98% (HPLC) |
Potent and selective FAK and Pyk2 inhibitor
| Chemical Name: | N-Methyl-4-[[4-[[[3-[methyl(methylsulfonyl)amino]-2-pyrazinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]benzamide |
| Purity: | ≥98% (HPLC) |
Potent FAK inhibitor; orally bioavailable
| Chemical Name: | 2-[[2-[[2-Methoxy-4-(4-morpholinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyridinyl]amino]-N-methylbenzamide |
| Purity: | ≥98% (HPLC) |
Dual FAK/PYK2 inhibitor
| Chemical Name: | N-Methyl-N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide |
| Purity: | ≥98% (HPLC) |
Potent focal adhesion kinase (FAK) inhibitor
| Chemical Name: | 2-[[5-Chloro-2-[[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino]-4-pyridinyl]amino]-N-methoxybenzamide |
| Purity: | ≥98% (HPLC) |
Potent and selective focal adhesion kinase (FAK) Degrader (PROTAC®)
| Chemical Name: | (2S,4R)-4-Hydroxy-1-((S)-2-(2-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide |
| Purity: | ≥98% (HPLC) |
Highly potent focal adhesion kinase (FAK) Degrader (PROTAC®)
| Chemical Name: | 1-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-N-[4-[[4-[[[2-[methyl(methylsulfonyl)amino]-3-pyridinyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]phenyl]-1H-1,2,3-triazole-4-carboxamide |
| Purity: | ≥98% (HPLC) |
