GABA-A R beta 3 Products
GABA-A-R beta 3 (GABA-A receptor subunit beta 3; also GABR3) is a 53 - 58 kDa member of the ligand-gated ion channel family of proteins. It is generally one of three beta-type subunits that contribute to a GABA-binding pentameric, postsynaptic chloride ion channel on neurons. Alternatively, it can apparently form a homopentameric channel that does not respond to GABA.
Mature human GABA-A-R beta 3 is 448 amino acids (aa) in length. It is a 4-transmembrane glycoprotein that contains an extended N-terminal extracellular region (aa 26 - 245) and a long cytoplasmic loop between aa 328 - 450. There are potential splice variants. One shows an alternate start site at Met65, while others contain either a 48 aa substitution for aa 1 - 228, a nine aa substitution for aa 1 - 80, or a 26 aa substitution for aa 1 - 26. Over aa 26 - 245, human and mouse GABA-A-R beta 3 are absolutely identical in aa sequence.
14 results for "GABA-A R beta 3" in Products
14 results for "GABA-A R beta 3" in Products
GABA-A R beta 3 Products
GABA-A-R beta 3 (GABA-A receptor subunit beta 3; also GABR3) is a 53 - 58 kDa member of the ligand-gated ion channel family of proteins. It is generally one of three beta-type subunits that contribute to a GABA-binding pentameric, postsynaptic chloride ion channel on neurons. Alternatively, it can apparently form a homopentameric channel that does not respond to GABA.
Mature human GABA-A-R beta 3 is 448 amino acids (aa) in length. It is a 4-transmembrane glycoprotein that contains an extended N-terminal extracellular region (aa 26 - 245) and a long cytoplasmic loop between aa 328 - 450. There are potential splice variants. One shows an alternate start site at Met65, while others contain either a 48 aa substitution for aa 1 - 228, a nine aa substitution for aa 1 - 80, or a 26 aa substitution for aa 1 - 26. Over aa 26 - 245, human and mouse GABA-A-R beta 3 are absolutely identical in aa sequence.
| Reactivity: | Human, Mouse |
| Details: | Rabbit Polyclonal |
| Applications: | IHC, WB |
![Western Blot: GABA-A R beta 3 Antibody [NBP3-10363]](https://resources.bio-techne.com/images/products/GABA-A-R-beta-3-Antibody-Western-Blot-NBP3-10363-img0001.jpg "Western Blot: GABA-A R beta 3 Antibody [NBP3-10363]")
| Applications: | WB |
![Western Blot: GABA-A R beta 3 Overexpression Lysate [NBL1-10922]](https://resources.bio-techne.com/images/products/GABA-A-Receptor-beta-3-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-10922-img0003.jpg "Western Blot: GABA-A R beta 3 Overexpression Lysate [NBL1-10922]")
| Applications: | WB |
![Western Blot: GABA-A R beta 3 Overexpression Lysate [NBP2-11263]](https://resources.bio-techne.com/images/products/GABA-A-Receptor-beta-3-Overexpression-Lysate-Adult-Normal-Western-Blot-NBP2-11263-img0001.jpg "Western Blot: GABA-A R beta 3 Overexpression Lysate [NBP2-11263]")
Competitive and selective GABAA antagonist
| Alternate Names: | Gabazine |
| Chemical Name: | 6-Imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid hydrobromide |
| Purity: | ≥98% (HPLC) |
GABAA agonist
| Alternate Names: | Gaboxadol |
| Chemical Name: | 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride |
| Purity: | ≥98% (HPLC) |
Positive allosteric modulator of GABAA receptors
| Alternate Names: | 3a,5a-THPROG |
| Chemical Name: | (3α,5α)-3-Hydroxy-pregnan-20-one |
Benzodiazepine inverse agonist
| Chemical Name: | N-Methyl-β-carboline-3-carboxamide |
| Purity: | ≥99% (HPLC) |
Active metabolite of oxcarbazepine (Cat. No. 3864)
| Alternate Names: | GP 47779 |
| Chemical Name: | 10,11-Dihydro-10-hydroxy-5H-dibenz(Z)[b,f]azepin-5-carboxamide |
| Purity: | ≥98% (HPLC) |
Postitive allosteric modulator of GABAA receptors
| Chemical Name: | (3α,5β)-3-Hydroxy-pregnan-20-one |
GABAA partial agonist; displays subtype selectivity
| Chemical Name: | 3-(2,5-Difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine |
| Purity: | ≥98% (HPLC) |
α5-selective GABAA inverse agonist
| Chemical Name: | 3-(1,1-Dimethylethyl)-7-(5-methyl-3-isoxazolyl)-2-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-pyrazolo[1,5-d][1,2,4]triazine |
| Purity: | ≥98% (HPLC) |
Benzodiazepine antagonist
| Alternate Names: | Ro 15-1788 |
| Chemical Name: | 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, ethyl ester |
| Purity: | ≥99% (HPLC) |
Benzodiazepine inverse agonist
| Chemical Name: | 4-Ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester hydrochloride |
| Purity: | ≥98% (HPLC) |
Benzodiazepine partial inverse agonist
| Chemical Name: | 8-Azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester |
| Purity: | ≥98% (HPLC) |
