GIPC1: Proteins and Enzymes

GIPC1, GIPC2, and GIPC3 are a family of central PDZ-domain proteins with GH1 and GH2 domains. GIPC1 has been shown to be highly expressed in gastric, pancreatic, colorectal and lung cancer cell lines. It also has a list of identified binding partners in vitro including many transmembrane proteins and cell surface molecules involved in adhesion. In vivo, there is evidence that suggests a role of GIPC1 in transmembrane protein trafficking through the Golgi stacks and possibly a role in the later stages of vesicle trafficking.