GPR15: cDNA Clones

GPR15, also known as Bob, is a seven-transmembrane G protein-coupled receptor that is expressed in CD4⁺ T cells and alveolar macrophages. GPR15 functions as a cellular co-receptor for some isolates of HIV-1, HIV-2, and SIV through interactions with several viral envelope proteins. Human GPR15 shares 96%-100% amino acid sequence identity with chimpanzee, macaque, and rhesus GPR15, and 76% with mouse GPR15.