GSK-3 beta Products
GSK-3 is a Ser/Thr kinase first identified as an inactivator of Glycogen Synthase. GSK-3 acts as a multifunctional downstream switch that determines the output of numerous signaling pathways. There are two mammalian GSK-3 isoforms encoded by distinct genes, GSK-3 alpha and GSK-3 beta, which are structurally similar, but functionally non-identical. GSK-3a is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3 alpha and GSK-3 beta share 85% amino acid identity. Dysregulated GSK-3 has been implicated in several diseases including type II diabetes, Alzheimer's disease, bipolar disorder, and cancer.
3 results for "GSK-3 beta" in Products
3 results for "GSK-3 beta" in Products
GSK-3 beta Products
GSK-3 is a Ser/Thr kinase first identified as an inactivator of Glycogen Synthase. GSK-3 acts as a multifunctional downstream switch that determines the output of numerous signaling pathways. There are two mammalian GSK-3 isoforms encoded by distinct genes, GSK-3 alpha and GSK-3 beta, which are structurally similar, but functionally non-identical. GSK-3a is inhibited by phosphorylation at S21 by Akt and other kinases. GSK-3 alpha and GSK-3 beta share 85% amino acid identity. Dysregulated GSK-3 has been implicated in several diseases including type II diabetes, Alzheimer's disease, bipolar disorder, and cancer.
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, CyTOF-ready, ICC, ICFlow |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG2b Monoclonal Clone #833916 |
| Applications: | WB, ICC |
