GSTM2: Proteins and Enzymes

The GSTM2 gene codes for a glutathione S-transferase Mu 2 protein that functions as a catalyst in various reactions in eukaryotes and prokaryotes such as converting reduced gluthathione to a large number of exogenous and endogenous hydrophobic electrophiles. Two isoforms exist: isoform 1 is 218 amino acids long at 25 kDA while isoform 2 is 191 amino acids long at 22 kDA. GSTM2 participates in glutathione methabolism and the metapathway biotransformation and interacts with genes GSTM3, GSTM1, GSTA2, ADH1A, and ITECPR1. GSTM2 has been investigated in its role in carcinoma, hepatitis, arthritis, lung cancer, breast cancer susceptibility, rheumatoid arthritis, and diabetes mellitus.