Hrk: Proteins and Enzymes
HRK (harakiri) is a 10 kDa pro-apoptotic member of the Bcl-2 family of apoptosis regulatory proteins. Hrk lacks significant homology to other Bcl-2 family members except for an 8-amino acid region that is similar to the BH3 domain of Bik (Bcl-2-interacting Killer). Hrk physically interacts with Bcl-2 and Bcl-xL, but not with the pro-apoptotic Bax, BAK, or Bcl-xS. Hrk regulates apoptosis by interacting selectively with survival-promoting Bcl-2 and Bcl-xL to induce cell death.
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Hrk: Proteins and Enzymes
HRK (harakiri) is a 10 kDa pro-apoptotic member of the Bcl-2 family of apoptosis regulatory proteins. Hrk lacks significant homology to other Bcl-2 family members except for an 8-amino acid region that is similar to the BH3 domain of Bik (Bcl-2-interacting Killer). Hrk physically interacts with Bcl-2 and Bcl-xL, but not with the pro-apoptotic Bax, BAK, or Bcl-xS. Hrk regulates apoptosis by interacting selectively with survival-promoting Bcl-2 and Bcl-xL to induce cell death.
| Source: | E. coli |
| Applications: | WB |
| Applications: | AC |