ICAT: Lysates
Human ICAT is a physiological inhibitor of the beta-catenin/Wnt signaling pathway that is found in both cytosol and nucleus. The molecule contains two domains, an alpha-helical N-terminal region, and an acidic, extended C-terminal region. The alpha-helical region binds to beta-Catenin, displacing CBP/p300, while the acidic C-terminus blocks Tcf interaction. Human ICAT is 97% aa identical to both mouse and bovine ICAT.
1 result for "ICAT Lysates" in Products
1 result for "ICAT Lysates" in Products
ICAT: Lysates
Human ICAT is a physiological inhibitor of the beta-catenin/Wnt signaling pathway that is found in both cytosol and nucleus. The molecule contains two domains, an alpha-helical N-terminal region, and an acidic, extended C-terminal region. The alpha-helical region binds to beta-Catenin, displacing CBP/p300, while the acidic C-terminus blocks Tcf interaction. Human ICAT is 97% aa identical to both mouse and bovine ICAT.
| Applications: | WB |
![Western Blot: ICAT/CTNNBIP1 Overexpression Lysate [NBP2-06663]](https://resources.bio-techne.com/images/products/CTNNBIP1-Overexpression-Lysate-Adult-Normal-Western-Blot-NBP2-06663-img0001.jpg "Western Blot: ICAT/CTNNBIP1 Overexpression Lysate [NBP2-06663]")