IL-17C: Proteins and Enzymes
Interleukin-17C is a 15-20 kDa disulfide-linked dimeric cytokine that plays an important role in mucosal immunity and chronic inflammation. IL-17C binds to IL-17 RE with high affinity and to IL-17 RA with low affinity. These two receptor chains can associate into a heterodimeric receptor for IL-17C. IL-17C expression is induced by inflammatory stimulation in colon and airway epithelial cells, keratinocytes, CD4+ T cells, macrophages, and dendritic cells. It is upregulated in various chronic inflammatory diseases including psoriasis, cystic fibrosis, and chronic obstructive pulmonary disease (COPD).
The interaction of IL-17C with IL-17 RE promotes mucosal immunity through the induction of anti-bacterial peptides and pro-inflammatory cytokines and chemokines. IL-17C action supports the integrity of the colon epithelium following infection-induced damage but also contributes to psoriatic skin thickening and the progression of arthritis.
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4 results for "IL-17C Proteins and Enzymes" in Products
4 results for "IL-17C Proteins and Enzymes" in Products
IL-17C: Proteins and Enzymes
Interleukin-17C is a 15-20 kDa disulfide-linked dimeric cytokine that plays an important role in mucosal immunity and chronic inflammation. IL-17C binds to IL-17 RE with high affinity and to IL-17 RA with low affinity. These two receptor chains can associate into a heterodimeric receptor for IL-17C. IL-17C expression is induced by inflammatory stimulation in colon and airway epithelial cells, keratinocytes, CD4+ T cells, macrophages, and dendritic cells. It is upregulated in various chronic inflammatory diseases including psoriasis, cystic fibrosis, and chronic obstructive pulmonary disease (COPD).
The interaction of IL-17C with IL-17 RE promotes mucosal immunity through the induction of anti-bacterial peptides and pro-inflammatory cytokines and chemokines. IL-17C action supports the integrity of the colon epithelium following infection-induced damage but also contributes to psoriatic skin thickening and the progression of arthritis.
Products:
| Source: | E. coli |
| Accession #: | Q9P0M4.1 |
| Applications: | Bind |
| Source: | E. coli |
| Accession #: | Q8K4C5.1 |
| Applications: | Bind |
| Source: | CHO |
| Accession #: | Q9P0M4 |
| Applications: | BA |
| Applications: | AC |