IL-18/IL-1F4 Products
IL-18 (Interleukin-18) is secreted by macrophages, dendritic cells, and epithelial cells. Circulating mature IL-18 is sequestered by soluble IL-18 binding proteins (IL-18 BP) that inhibit IL-18 bioactivity. IL-18 signals through a receptor complex that contains IL-18 R alpha IL-18 R beta. It synergizes with other cytokines to activate NK, Th1, and Th17 cells and to increase the production of IFN-gamma. It can also promote Th2 cytokine release which reduces the effectiveness of antiviral responses. Increased levels of active IL-18 contribute to the severity of autoimmunity and hypertension, while deficiency of IL-18 results in symptoms of metabolic syndrome. In cancer, IL-18 stimulates Th1 and NK cells to target tumor cells, but it can also promote angiogenesis, metastasis, and tumor cell immune evasion.
290 results for "IL-18/IL-1F4" in Products
290 results for "IL-18/IL-1F4" in Products
IL-18/IL-1F4 Products
IL-18 (Interleukin-18) is secreted by macrophages, dendritic cells, and epithelial cells. Circulating mature IL-18 is sequestered by soluble IL-18 binding proteins (IL-18 BP) that inhibit IL-18 bioactivity. IL-18 signals through a receptor complex that contains IL-18 R alpha IL-18 R beta. It synergizes with other cytokines to activate NK, Th1, and Th17 cells and to increase the production of IFN-gamma. It can also promote Th2 cytokine release which reduces the effectiveness of antiviral responses. Increased levels of active IL-18 contribute to the severity of autoimmunity and hypertension, while deficiency of IL-18 results in symptoms of metabolic syndrome. In cancer, IL-18 stimulates Th1 and NK cells to target tumor cells, but it can also promote angiogenesis, metastasis, and tumor cell immune evasion.
| Sensitivity: | 5.15 pg/mL |
| Applications: | ELISA |
| Assay Range: | 15.6 - 1,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Saliva, Urine) |
Simple Plex Human IL-18/IL-1F4 assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.
| Applications: | Simple Plex |
| Assay Range: | 11.7 - 750 pg/mL |
| Applications: | ELISA |
| Source: | E. coli |
| Accession #: | P70380 |
| Applications: | BA |
| Sensitivity: | 25 pg/mL |
| Applications: | ELISA |
| Assay Range: | 25.6 - 1,000 pg/mL |
Contains 4 membranes - each spotted in duplicate with 36 different cytokine antibodies
Analyzed by SEC-MALS
| Source: | E. coli |
| Accession #: | Q14116 |
| Applications: | BA |
| Assay Range: | 46.9 - 3,000 pg/mL |
| Applications: | ELISA |
Human IL-18/IL-1F4 Quantikine ELISA Kit is now available!
| Sensitivity: | 12.5 pg/mL |
| Applications: | ELISA |
| Assay Range: | 25.6 - 1,000 pg/mL |
Build your own multi-plex biomarker immunoassay panel for Ella™. Highly precise and reproducible. Choose from more than 250 fully validated target analytes.
| Applications: | Simple Plex |
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #125-2H |
| Applications: | IP, Neut |
Luminex High Performance Assays go through rigorous development, validation, and quality control testing to ensure you are getting the best performance out of your multiplex assay. Panels are customizable so you can order a selection of the analytes or the entire panel.
Control for use with Human and Non-Human Primate IL-18/IL-1F4 Simple Plex Cartridge Kit
| Applications: | Ctrl, Simple Plex |
Simple Plex 32x4 panel containing IL-12 p70, IL-15, IL-18/IL-1F4, and IL-2 with sample diluent SD13. Part # starting with ST01 ships in 2-3 days. Sample type indicated with CS (cell culture).
| Applications: | Simple Plex |
| Source: | E. coli |
| Accession #: | P97636.1 |
| Applications: | BA |
| Reactivity: | Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Neut |
| Reactivity: | Human, Rhesus Macaque |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Simple Western, ELISA, ICC, KO, +1 More |
| Reactivity: | Human |
| Details: | Rat IgG2a Monoclonal Clone #159-12B |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #925008 |
| Applications: | ELISA, CyTOF-ready, ICC, ICFlow |
For use with catalog number DL180
| Applications: | Ctrl |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #74 |
| Applications: | IP |
A New rh IL-18 is Available! Competitively priced; Higher purity; Lower endotoxin specifications; Made in-house!
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Simple Western, KO |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #74801 |
| Applications: | WB, CyTOF-ready, ICFlow, KO |
