Integrin alpha V beta 3: Proteins and Enzymes
Integrin alpha V beta 3 (aVb3) is a heterodimeric adhesion protein that is highly expressed on endothelial cells and osteoclasts. Active cell surface aVb3 binds to the extracellular matrix proteins Vitronectin, Fibronectin, Fibrinogen, and Thrombospondin. It is essential for the maturation of osteoclasts and their bone resorption activity. Loss of aVb3 function during osteoclastogenesis causes osteoporosis. In addition, aVb3 enhances VEGF R2 mediated angiogenesis, IGF-1 mediated tumor cell invasiveness, and cell entry by several viruses.
Products:
3 results for "Integrin alpha V beta 3 Proteins and Enzymes" in Products
3 results for "Integrin alpha V beta 3 Proteins and Enzymes" in Products
Integrin alpha V beta 3: Proteins and Enzymes
Integrin alpha V beta 3 (aVb3) is a heterodimeric adhesion protein that is highly expressed on endothelial cells and osteoclasts. Active cell surface aVb3 binds to the extracellular matrix proteins Vitronectin, Fibronectin, Fibrinogen, and Thrombospondin. It is essential for the maturation of osteoclasts and their bone resorption activity. Loss of aVb3 function during osteoclastogenesis causes osteoporosis. In addition, aVb3 enhances VEGF R2 mediated angiogenesis, IGF-1 mediated tumor cell invasiveness, and cell entry by several viruses.
Products:
| Source: | CHO |
| Accession #: | NP_002201 (Integrin alpha V) & AAA52589 (Integrin beta 3) |
| Applications: | Bind |
| Source: | CHO |
| Accession #: | P43406 (Integrin alpha V) & O54890 (Integrin beta 3) |
| Applications: | BA |
| Source: | CHO |
| Accession #: | XP_005573729.1 (Integrin alpha V) & XP_005584667.1 (Int |
| Applications: | BA |
