IRGM: Proteins and Enzymes

Members of the p47 immunity-related GTPase (IRG) family, including IRGM, play an important role in the murine immune system; however, in humans this resistance system is greatly reduced. There is evidence that human IRGM plays a role in autophagy and control of intracellular mycobacteria (Bepken et al., 2005; Singh et al., 2006 [PubMed 16888103]).[supplied by OMIM]