LAG-3 Products
LAG-3 (Lymphocyte activation gene-3; CD223) is a transmembrane protein that binds to MHC class II molecules and negatively regulates T cell receptor signaling. It is expressed on activated T cells, NK cells, and plasmacytoid dendritic cells (pDC). LAG-3 limits the expansion of activated T cells and pDC in response to select stimuli. Proteolytic shedding of LAG-3 enables normal T cell activation by removing the negative regulation. Binding of a homodimerized soluble LAG-3/Ig fusion protein to MHC class II molecules induces maturation of immature DC as well as secretion of pro-inflammatory cytokines by cytotoxic CD8+ T cells and NK cells.
419 results for "LAG-3" in Products
419 results for "LAG-3" in Products
LAG-3 Products
LAG-3 (Lymphocyte activation gene-3; CD223) is a transmembrane protein that binds to MHC class II molecules and negatively regulates T cell receptor signaling. It is expressed on activated T cells, NK cells, and plasmacytoid dendritic cells (pDC). LAG-3 limits the expansion of activated T cells and pDC in response to select stimuli. Proteolytic shedding of LAG-3 enables normal T cell activation by removing the negative regulation. Binding of a homodimerized soluble LAG-3/Ig fusion protein to MHC class II molecules induces maturation of immature DC as well as secretion of pro-inflammatory cytokines by cytotoxic CD8+ T cells and NK cells.
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, CyTOF-reported |
| Source: | NS0 |
| Accession #: | P18627 |
| Applications: | BA |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Assay Range: | 93.8 - 6,000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #874501 |
| Applications: | WB, Flow, CyTOF-reported |
| Source: | NS0 |
| Accession #: | Q61790 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #874501 |
| Applications: | Flow |
| Reactivity: | Mouse |
| Details: | Rat IgG2b Monoclonal Clone #631501 |
| Applications: | Flow |
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #BLR028F |
| Applications: | IHC, WB, ICC/IF, IP |
![Western Blot: LAG-3 Antibody (BLR028F) [NBP2-76403]](https://resources.bio-techne.com/images/products/LAG-3-Antibody-BLR028F-Western-Blot-NBP2-76403-img0003.jpg "Western Blot: LAG-3 Antibody (BLR028F) [NBP2-76403]")
| Reactivity: | Mouse |
| Details: | Rat IgG2b Monoclonal Clone #631501 |
| Applications: | Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #874501 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow |
Recombinant Monoclonal Antibody.
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #BLR027F |
| Applications: | IHC, WB, ICC/IF, Flow, IP, +1 More |
![Western Blot: LAG-3 Antibody (BLR027F) [NBP2-76402]](https://resources.bio-techne.com/images/products/LAG-3-Antibody-BLR027F-Western-Blot-NBP2-76402-img0007.jpg "Western Blot: LAG-3 Antibody (BLR027F) [NBP2-76402]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #874501 |
| Applications: | Flow |
![LAG-3 Antibody (874501) [mFluor Violet 610 SE]](https://resources.bio-techne.com/images/products/fab23193mfv610_mouse-lag-3-mab-874501-mfluor-violet-610-se-flow-cytometry-912024143342..jpg "Detection of LAG-3 in PBMCs treated with 5 ug/mL PHA for 5 days cells by Flow Cytometry.")
| Reactivity: | Mouse |
| Details: | Rat IgG2b Monoclonal Clone #631501 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #874501 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #333210 |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #874501 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #L4-PL33 |
| Applications: | IHC, WB, ICC/IF, ELISA, Flow, +1 More |
![Western Blot: LAG-3 Antibody (L4-PL33)Azide Free [NBP3-05777]](https://resources.bio-techne.com/images/products/LAG-3-Antibody-L4-PL33-Azide-Free-Western-Blot-NBP3-05777-img0001.jpg "Western Blot: LAG-3 Antibody (L4-PL33)Azide Free [NBP3-05777]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, MA |
![Immunohistochemistry-Paraffin: LAG-3 Antibody [NBP1-85781]](https://resources.bio-techne.com/images/products/LAG-3-Antibody-Immunohistochemistry-Paraffin-NBP1-85781-img0007.jpg "Immunohistochemistry-Paraffin: LAG-3 Antibody [NBP1-85781]")
| Reactivity: | Mouse |
| Details: | Rat IgG2b Monoclonal Clone #631501 |
| Applications: | Flow |