LAG-3 Products
LAG-3 (Lymphocyte activation gene-3; CD223) is a transmembrane protein that binds to MHC class II molecules and negatively regulates T cell receptor signaling. It is expressed on activated T cells, NK cells, and plasmacytoid dendritic cells (pDC). LAG-3 limits the expansion of activated T cells and pDC in response to select stimuli. Proteolytic shedding of LAG-3 enables normal T cell activation by removing the negative regulation. Binding of a homodimerized soluble LAG-3/Ig fusion protein to MHC class II molecules induces maturation of immature DC as well as secretion of pro-inflammatory cytokines by cytotoxic CD8+ T cells and NK cells.
419 results for "LAG-3" in Products
419 results for "LAG-3" in Products
LAG-3 Products
LAG-3 (Lymphocyte activation gene-3; CD223) is a transmembrane protein that binds to MHC class II molecules and negatively regulates T cell receptor signaling. It is expressed on activated T cells, NK cells, and plasmacytoid dendritic cells (pDC). LAG-3 limits the expansion of activated T cells and pDC in response to select stimuli. Proteolytic shedding of LAG-3 enables normal T cell activation by removing the negative regulation. Binding of a homodimerized soluble LAG-3/Ig fusion protein to MHC class II molecules induces maturation of immature DC as well as secretion of pro-inflammatory cytokines by cytotoxic CD8+ T cells and NK cells.
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #874501 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #874501 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #874501 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #874501 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #CL14773 |
| Applications: | IHC |
| Applications: | ELISA |
| Reactivity: | Mouse |
| Details: | Rat IgG2b Monoclonal Clone #631501 |
| Applications: | Flow |
| Reactivity: | Mouse |
| Details: | Rat IgG2b Monoclonal Clone #631501 |
| Applications: | Flow |
| Reactivity: | Mouse |
| Details: | Rat IgG2b Monoclonal Clone #631501 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #874501 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG2B Monoclonal Clone #OTI8F6 |
| Applications: | IHC, WB, Flow |
![Western Blot: LAG-3 Antibody (OTI8F6) [NBP2-45581]](https://resources.bio-techne.com/images/products/LAG-3-Antibody-OTI8F6-Western-Blot-NBP2-45581-img0004.jpg "Western Blot: LAG-3 Antibody (OTI8F6) [NBP2-45581]")
| Reactivity: | Human |
| Details: | Mouse IgG2B Monoclonal Clone #CL14765 |
| Applications: | IHC |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #PSH0-44 |
| Applications: | IHC, WB, ICC/IF |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #PS01-33 |
| Applications: | IHC, WB, ICC/IF |
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #874525 |
| Applications: | WB, Flow |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Human IgG4 Monoclonal |
| Applications: | ELISA, Flow, Func |
| Reactivity: | Mouse |
| Details: | Rat IgG2B Monoclonal Clone #631501 |
| Applications: | Flow, CyTOF-ready |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Human IgG4 Monoclonal |
| Applications: | ELISA, Flow, Func |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Human IgG4 Monoclonal |
| Applications: | ELISA, Flow, Func |
| Applications: | AC |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #874501 |
| Applications: | WB, Flow, CyTOF-ready |
| Reactivity: | Mouse |
| Details: | Rat IgG2B Monoclonal Clone #631501 |
| Applications: | Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #874501 |
| Applications: | WB, Flow, CyTOF-ready |