NDRG1: Proteins and Enzymes

NDRG1 (N-myc downstream-regulated gene 1; also DRG-1 and Cap43) is a 43 kDa member of the NDRG family of proteins. It is ubiquitously expressed, found in fibroblasts, endothelial cells, respiratory epithelium and prostate epithelium. NDRG1 is highly expressed in non-proliferating, differentiating tissue. Human NDRG1 is 394 amino acids (aa) in length. It contains an NDGR domain (aa 286 - 316) plus three tandem 10 aa hydrophilic repeats (aa 339 - 368). There are three potential isoform variants. Two involve alternate start sites at Met82 and Met286, while a third shows a four aa substitution for aa 1 - 34. Over aa 11 - 267, human NDRG1 is 95% aa identical to mouse NDRG1.