NIK/MAP3K14: Small Molecules and Peptides
NIK (nuclear factor inducing kinase), also called MAP3K14 or MAP4K4, is a widely expressed 947 amino acid (aa), approximately 100 kDa cytoplasmic protein of the MAP kinase family. NIK participates in a non-canonical NFkappaB signaling cascade in which its activity and expression are elevated by TNF and related ligands. NIK activates IKK alpha/beta, which releases NFkappaB subunits for translocation to the nucleus.
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NIK/MAP3K14: Small Molecules and Peptides
NIK (nuclear factor inducing kinase), also called MAP3K14 or MAP4K4, is a widely expressed 947 amino acid (aa), approximately 100 kDa cytoplasmic protein of the MAP kinase family. NIK participates in a non-canonical NFkappaB signaling cascade in which its activity and expression are elevated by TNF and related ligands. NIK activates IKK alpha/beta, which releases NFkappaB subunits for translocation to the nucleus.
Potent NIK inhibitor
| Chemical Name: | 4-[3-[2-Amino-5-(2-methoxyethoxy)-4-pyrimidinyl]-1H-indol-5-yl]-2-methyl-3-butyn-2-ol |
| Purity: | ≥98% |
