Patched 1/PTCH: cDNA Clones

Patched homolog 1 (PTC1) is a 170 - 175 kDa member of the Patched family of proteins. It is found on multiple cells types and forms a constitutive, inactivating complex with Smoothened. Upon SHH binding to PTC1, Smoothened is released and initiates downstream signaling.

Mouse PTC1 is a 12 transmembrane, 1434 aa glycoprotein that contains ...